真菌毒素生物降解

酶理性设计与改造

1. 国家自然科学基金面上项目：定向进化提高玉米赤霉烯酮降解酶ZenH的耐酸性及其分子机制研究，2024-2027（参与）

2. 国家重点研发计划项目子任务：真菌毒素高效降解酶异源表达系统的构建及降解机理解析，2023-2028（参与）

1.  Hu J, Wu Y, Zhang M, et al. Multi-pronged design enhances thermostability of zearalenone hydrolase ZenR for enzymatic detoxification of maize flour. Bioresource Technology. 2026.

2.  Hu J†, Wang G†, Hou M, et al. New hydrolase from Aeromicrobiumsp. HA for the biodegradation of zearalenone: Identification, mechanism, and application. Journal of Agricultural and Food Chemistry. 2023.

3.  Hu J, Du S, Qiu H, et al. A hydrolase produced by Rhodococcus erythropolis HQ is responsible for the detoxification of zearalenone. Toxins. 2023