致病菌的快速检测与控制新技术研究

1.科技部高端外国专家引进计划(G2021014015L)，噬菌体源“蛋白抗生素”的研究与开发，2021.1-2022.12

2.国家自然科学基金青年基金项目(21505056)，基于高硼亲和力磁性纳米粒子的糖肤类抗生素适配件筛选方法研究，2016.01-2018.12。

3.江苏省自然科学基金(BK20221430)，噬菌体裂解酶自组装水凝胶设计及缓释抑菌机制研究，2022.7-2025.6

4.乳业生物技术国家重点实验室开放基金(SKLDB2022-004)，乳品中痕量金黄色葡萄球菌和沙门氏菌活菌的快速定量检测方法研究，2022.6-2024.5；

5.院国际合作基金，基于宽谱噬菌体的致病活菌的快速检测技术，2023.7-2023.12；

6.院国际合作基金，噬菌体常温保存及增效关键材料与技术研发，2020.7-2021.12；

1. Zeng Qin, Zou HuiYu, Deng TingLiu, Wu Wuming*, Wang Heye*, Deng ChunYan*, Photoelectrochemical/Colorimetric Dual-mode  Specific Detection of Staphylococcus aureus Based on the Enzymatic Reaction Triggered by Catalase from Lysed Bacteria. 2024, DOI: 10.1021/acs.analchem.4c02177.

2.  Zhou Jingjing, Deng Tingliu, Zeng Qin, Wang Heye*, Deng Chunyan*. An electrochemical biosensor for sensitive detection of live Salmonella in food via MXene amplified methylene blue signals and electrostatic immobilization of bacteriophages. Microchimica Acta. 2024, DOI.org/10.21203/rs.3.rs-4649888/v1.

3.  Liu Hui; Ji Xing; Sun Haichang; Billington Craig; Hou Xiang; Soleimani-Delfan Abbas; Wang Ran; Wang heye*; Zhang Lili* ; Diverse Genotypes of Cronobacter spp. Associated with Dairy Farm Systems in Jiangsu and Shandong Provinces in China, Foods, 2024, 13: 871. 

4.  HuYuwei, Zeng Qin, Hu Yifan, He Jinyun, Wang Heye, Deng Chunyan*, Li Dai*. MXene/zinc ion embedded agar/sodium alginate hydrogel for rapid and efficient sterilization with photothermal and chemical synergetic therapy. Talanta, 2024, 266, 125101.

5.   Liu Hui, Ji Xing , Wang Heye, Hou Xiang, Sun Haichang, Billington Craig, Zhang Lili, Wang Xiaoye, Wang Ran. Genomic epidemiology and characterization of Staphylococcus aureus isolates from raw milk in Jiangsu, China: emerging broader host tropism strain clones ST59 and ST398. Frontiers In Microbiology, 2023, 14: 1266715.

6.  王合叶; 徐沁妍; 姜越; 张莉莉; 孙利厂; 王冉 ; 噬菌体粉剂的制备及抗逆性与稳定性, 微生物学通报, 2021, 48(9): 3109-3115.

7.  Wang heye; Yang YaLi; Wang Yue; Zhang ShuaiFeng; Li Li*; Development of disk-shaped monolithic microplates for detecting multiple mycotoxins, Analytical Methods, 2019, 11: 6084-6091

8.  Wang heye; Zhang Xiaohan; Liu Yibo; Liu Juewen*; Stabilization of Liposomes by Perfluorinated Compounds, ACS Omega, 2018, 3: 15353-15360.

授权与申请专利：

1.王合叶；王冉；张莉莉；包红朵；魏瑞成；张辉；何涛；周艳. 一种噬菌体复合粉剂及其制备方法与应用. ZL202110795145.5 [P]. 2024-6-21.

2.王合叶; 王冉 ; 一种粒径均匀的树枝状高分子修饰磁性微球及其制备方法和应用, 2017-11-16, 中国, ZL201711144386. 3 [P]. 2020-05-26

3.王冉；孙利厂；张莉莉；王合叶；何涛；庞茂达. 一种用于喷洒噬菌体生物制剂的智能雾化装置的应用方法. ZL202110449755.X [P]. 2024-05-14.

4.王合叶; 王冉; 张莉莉; 孙利厂 ; 一种基于噬菌体识别和纳米金的可视化检测活菌的方法. 2022-11-17, 中国, CN202211438482.X.

5.王合叶, 张莉莉, 孙海畅, 王冉, 孙利厂. 一种噬菌体裂解酶温敏缓释水凝胶与应用. 2024-6-12，中国，CN202410753904.5.

6.张莉莉, 王合叶, 孙海畅, 王冉, 孙利厂. 一种抗降解的宽谱金黄色葡萄球菌噬菌体裂解酶及应用. 2024-5-14，中国，CN202410594923.8. 

7. 张莉莉, 王合叶, 孙海畅, 孙利厂, 王冉. 一种宽谱金黄色葡萄球菌噬菌体裂解酶及应用. 2023-6-12，中国，CN202310688631.6.