李俊，博士，副研究员。主要研究领域：动物源细菌耐药性传播机制及基于噬菌体的防控策略研究。近年来，先后主持参与国家自然科学基金项目、江苏省自然科学基金项目、江苏省农业科学院探索性颠覆性创新研究课题等项目6项。获得神农中华农业科技奖、江苏省农学会技术创新奖等科技奖励3项。发表论文30余篇，其中以第一作者在Antimicrobial Agents and Chemotheraphy, Veterinary Microbiology, Microbiology Spectrum, Frontiers in Microbiolog等杂志发表SCI论文9篇，获国家发明专利授权2项；参编专著1部。
一、主持或参加的科研项目
1. 国家自然科学基金青年科学基金项目，“外膜囊泡介导tet(X)变体基因及Tet(X)药物灭活酶水平转移机制研究”，32102728，30万元，2022/01-2024/12，主持。
2. 江苏省自然科学基金青年科学基金项目，“环丙沙星压力下胞内寄生猪鼻支原体耐药应答机制研究”，BK20190261，20万元，2019/07-2022/06，主持。
3. 江苏省农业科学院探索性颠覆性创新项目，“基于T4SS靶向型合成噬菌体的细菌耐药性精准防控技术研究”，ZX(21)1224，36万元，2021/07-2023/12，主持。
4. 华中农业大学博士研究生创新研究工程项目，“恩诺沙星作用下鸡肠道内大肠杆菌及乳酸杆菌耐药应答机制研究”，2014bs14，2万元，2015/01-2015/12，主持。
5. 国际组织合作项目，“One Health interventions to prevent or reduce the development and transmission of antimicrobial resistance”，200001，225.6万元，2022/01-2024/12，参与。
6. 国家自然科学基金面上项目，“沙门氏菌噬菌体肠道定植对微生物群落调控及肠粘膜屏障修复机制研究”，32273095，55万元，2023/01-2026/12，参与。
二、获得科技奖励
1. 神农中华农业科技奖优秀创新团队奖，“江苏省农业科学院动物支原体病防控创新团队”，2021.10，排名第13。
2. 首届江苏省畜牧兽医学会科技奖一等奖，“可转移替加环素耐药基因tet(X)变体的发现、传播机制与控制策略研究”，2021.11，排名第8。
3. 第四届江苏省农学会技术创新奖二等奖，“养殖业抗生素在养-种循环中污染风险及防控关键技术研究与应用”，2021.12，排名第11。
三、发表论文
1. Tao He*, Jun Li*, Lan Gong, Yang Wang, Ruichao Li, Xing Ji, Fengting Luan, Minmin Tang, Lei Zhu, Ruicheng Wei, Ran Wang. Comprehensive Analysis of Antimicrobial, Heavy Metal, and Pesticide Residues in Commercial Organic Fertilizers and Their Correlation with Tigecycline Resistant tet(X)-Variant Genes. Microbiology Spectrum. 2023, 11(2):e0425122.
2. Xingqi Tong*, Jun Li*, Ruicheng Wei, Lan Gong, Xing Ji, Tao He, Ran Wang. RW-BP100-4D, A Promising Antimicrobial Candidate with Broad-Spectrum Bactericidal Activity. Frontiers in Microbiology. 2022, 12:815980.
3. Jun Li, Yanna Wei, Jia Wang, Yao Li, Guoqing Shao, Zhixin Feng, Qiyan Xiong. Characterization of Mutations in DNA Gyrase and Topoisomerase IV in Field Strains and In Vitro Selected Quinolone-Resistant Mycoplasma hyorhinis Mutants. Antibiotics. 2022, 11:494.
4. Jun Li, Jia Wang, Jia Shao, Yao Li, Yanfei Yu, Guoqing Shao, Zhixin Feng, Qiyan Xiong. The Variable Lipoprotein Family Participates in the Interaction of Mycoplasma hyorhinis with Host Extracellular Matrix and Plasminogen. Veterinary Microbiology. 2022, 265:109310.
5. Shuge Wang, Anxiong Huang, Yufeng Gu, Jun Li, Lingli Huang, Xu Wang, Yanfei Tao, Zhenli Liu, Congming Wu, Zonghui Yuan, Haihong Hao. Rational Use of Danofloxacin for Treatment of Mycoplasma gallisepticum in Chickens Based on the Clinical Breakpoint and Lung Microbiota Shift. Antibiotics. 2022, 11:403.
6. Zhenzhen Zhang, Haiyan Wang, Xing Xie, Rong Chen, Jun Li, Bo Ni, Pei Yu, Zunfeng Liu, Guoqing Shao, Qiyan Xiong, Yanna Wei, Beibei Liu, Zhixin Feng, Xiang Zhou, Chao Zhang. Long-Residence Pneumonia Vaccine Developed Using PEG-Grafted Hybrid Nanovesicles from Cell Membrane Fusion of Mycoplasma and IFN-γ-Primed Macrophages. Small. 2021, 2101183.
7. Jia Wang, Yao Li, Longji Pan, Jun Li, Yanfei Yu, Beibei Liu, Muhammad Zubair, Yanna Wei, Bala Pillay, Ademola Olufolahan Olaniran, Thamsanqa E. Chiliza. Guoqing Shao, Zhixin Feng, Qiyan Xiong. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) moonlights as an adhesin in Mycoplasma hyorhinis adhesion to epithelial cells as well as a plasminogen receptor mediating extracellular matrix degradation. Veterinary Research. 2021, 52:80.
8. Zihui Xu, Anxiong Huang, Xun Luo, Peng Zhang, Lingli Huang, Xu Wang, Kun Mi, Shiwei Fang, Xiao Huang, Jun Li, Zonghui Yuan, Haihong Hao. Exploration of Clinical Breakpoint of Danofloxacin for Glaesserella parasuis in Plasma and in PELF. Antibiotics. 2021, 10:808.
9. Anxiong Huang, Shuge Wang, Jinli Guo, Yufeng Gu, Jun Li, Lingli Huang, Xu Wang, Yanfei Tao, Zhenli Liu, Zonghui Yuan, Haihong Hao. Prudent Use of Tylosin for Treatment of Mycoplasma gallisepticum Based on its Clinical Breakpoint and Lung Microbiota Shift. Frontiers in Microbiology. 2021, 1:712473.
10. Yufeng Gu, Shuge Wang, Lulu Huang, Wei Sa, Jun Li, Junhong Huang, Menghong Dai, Guyue Cheng. Development of Resistance in Escherichia coli ATCC25922 under Exposure of Sub-Inhibitory Concentration of Olaquindox. Antibiotics. 2020, 9:791.
11. Jun Li*, Haihong Hao*, Menghong Dai, Heying Zhang, Jianan Ning, Guyue Cheng, Muhammad Abu Bakr Shabbir, Abdul Sajid, Zonghui Yuan. Resistance and Virulence Mechanisms of Escherichia coli Selected by Enrofloxacin in Chicken. Antimicrobial Agents and Chemotherapy. 2019, 63:e01824-18.
12. Jun Li, Heying Zhang, Jianan Ning, Abdul Sajid, Guyue Cheng, Zonghui Yuan, Haihong Hao. The Nature and Epidemiology of OqxAB, A Multidrug Efflux Pump. Antimicrobial Resistance and Infection Control. 2019, 8:44.
13. Jun Li*, Shuyu Xie*, Saeed Ahmed, Funan Wang, Yufeng Gu, Chaonan Zhang, Ximan Chai, Yalan Wu, Jinxia Cai, Guyue Cheng. Antimicrobial Activity and Resistance: Influencing Factors. Frontiers in Pharmacology. 2017, 8:364.
14. Jun Li, Haihong Hao, Guyue Cheng, Chunbei Liu, Saeed Ahmed, Muhammad A.B. Shabbir, Hafiz I. Hussain, Menghong Dai, Zonghui Yuan. Microbial Shifts in the Intestinal Microbiota of Salmonella Infected Chickens in Response to Enrofloxacin. Frontiers in Microbiology. 2017, 8:1711.
15. Jun Li, Haihong Hao, Guyue Cheng, Xu Wang, Saeed Ahmed, Muhammad Abu Bakr Shabbir, Zhenli Liu, Menghong Dai, Zonghui Yuan. The effects of different enrofoxacin dosages on clinical efficacy and resistance development in chickens experimentally infected with Salmonella Typhimurium. Scientific Reports. 2017, 7:11676.
16. Saeed Ahmed, Jianna Ning, Guyue Cheng, Ijaz Ahmad, Jun Li, Mingyue Liu, Wei Qu, Mujahid Iqbal, M.A.B. Shabbir, Zonghui Yuan. Receptor-based Screening Assays for the Detection of Antibiotics Residues-A Review. Talanta. 2017, 166:176-186.
17. Peng Zhang, Haihong Hao,Jun Li, Ijaz Ahmad, Guyue Cheng, Dongmei Chen, Yanfei Tao, Lingli Huang, Yulian Wang, Menghong Dai, Zhenli Liu, Zonghui Yuan. The Epidemiologic and Pharmacodynamic Cutoff Values of Tilmicosin against Haemophilus parasuis. Frontiers in Microbiology. 2016, 7:385.
18. Muhammad Abu Bakr Shabbir, Haihong Hao, Muhammad Zubair Shabbir, Hafiz Iftikhar Hussain, Zahid Iqbal, Saeed Ahmed, Adeel Sattar, Mujahid Iqbal, Jun Li, Zonghui Yuan. Survival Evolution of CRISPR-Cas System in Prokaryotes and Its Applications. Frontiers in Immunology. 2016, 7:375.
19. 李俊，李倩茹，吉星，何涛，魏瑞成，王冉. 细菌外膜囊泡介导水平基因转移机制研究进展. 国外医药抗生素分册. 2023, 44(5):178-184.
20. 吉星，李俊，王冉，何涛. 常见益生菌耐药性研究进展. 江苏农业学报. 2022, 38(6):1722-1728.
21. 甘源，邵佳，李俊，王佳，韦艳娜，华利忠，谢星，袁厅，刘蓓蓓，邵国青，冯志新，熊祺琰. 猪鼻支原体的流行特点及防治措施. 国外医药抗生素分册. 2022, 43(1):17-23.
22. 李俊，牛志强，侯博，华利忠，韦艳娜，刘蓓蓓，王丽，谢星，张珍珍，熊祺琰，邵国青，李新国，冯志新. 福建地区鸡滑液囊支原体的分离、药物敏感性及耐药株全基因组序列分析. 江苏农业科学. 2021, 49(12):117-124.
23. 李俊，韦艳娜，刘蓓蓓，熊祺琰，邵国青，肖海君，谭涛，冯志新. 猪支原体对枝原净和泰农的药物敏感性分析. 国外畜牧学-猪与禽. 2020, 40(12):25-30.
24. 潘垄基，李俊，王佳，刘蓓蓓，袁厅，谢星，王丽，韦艳娜，冯志新，邵国青，吴庆霞，熊祺琰. 猪鼻支原体3-磷酸甘油醛脱氢酶表达及黏附细胞功能研究. 扬州大学学报. 2020, 41(3):16-36.
25. 甘源，谢星，张磊，熊祺琰，杨浩，刘蓓蓓，韦艳娜，王海燕，于岩飞，白昀，袁厅，李俊，郝飞，华利忠，邵国青，冯志新. 猪肺炎支原体人工感染引起易感猪各肺叶病变差异的研究. 扬州大学学报. 2020, 41(4):71-76.
26. 程古月，李俊，谷宇峰，贾思凡，郝海红，王旭，刘振利，戴梦红，袁宗辉. 世界卫生组织、欧盟和中国抗生素耐药性监测现状. 中国抗生素杂志. 2018, 43(6):665-674.
27. 黄安雄，王淑歌，李俊，黄伶俐，王旭，刘振利，郝海红，袁宗辉. 鸡毒支原体对大环内酯类抗生素的耐药判定标准研究现状. 中国兽医学报. 2018, 38(12):2414-2431.
28. 程古月，李俊，郝海红，王旭，刘振利，袁宗辉. 黏杆菌素在动物中的研究与应用. 2017, 37(8):1617-1626.
29. 高海娇，程古月，王玉莲，宁佳囡，陈婷，李俊，郝海红，袁宗辉. 细菌主要外排泵及其调控蛋白研究进展. 2017, 48(11):2023-2033.
30. 李俊，程古月，袁宗辉. 药理学原则在抗微生物药给药方案设计中的应用. 国外医药抗生素分册. 2016, 37(3):104-106.
31. 程古月*，李俊*，郝海红，戴梦红，王旭，刘振利，袁宗辉. 黏杆菌素的抗菌机制及耐药性研究. 中国抗生素杂志. 2016, 41(7):481-492.
32. 程古月，李俊，袁宗辉. 兽医需要新型创新绿色抗微生物药. 国外医药抗生素分册. 2016, 37(3):107-108.
33. 程古月，李俊，郝海红，袁宗辉. 兽用创新环保抗菌药的开发及其重要性. 国外医药抗生素分册. 2016, 37(6):249-258.
四、授权国家发明专利
1. 李俊，何涛，王冉，魏瑞成，龚兰，吉星. 一种T4SS靶向型噬菌体vB-EcoM-X4及其应用. 2022.09.02, 中国，ZL202110870879.5
2. 何涛，童星琦，王冉，魏瑞成，李俊，龚兰. 一种抗菌肽HT11及其衍生物和应用. 2023.02.17, 中国，ZL202110689519.5
五、联系信息
地址：江苏省农业科学院农产品质量安全与营养研究所419室
邮箱：lijunjaas@126.com